Case Report of Chronic Pancreatitis in aPatient with Celiac Disease and Extra-Intestinal Manifestations of Celiac Disease: Report of a Case and a Literature Review

Celiac disease is characterized by both inflammation of the small intestine and villous atrophy. It is triggered by exposure to dietary gluten in genetically susceptible individuals. Celiac diseases frequently manifest themselves in a diverse variety of extra intestinal symptoms which are well-documented. There is now evidence of the association of pancreaticobiliary diseases in patients with celiac disease, and it has been reported that celiac disease is associated with an increased risk of pancreatitis and pancreatic insufficiency. In the last 30 years, celiac cases exhibiting extra-intestinal symptoms were not well understood and no clear association with pancreaticobiliary diseases had yet been established. A young female with chronic pancreatitis was referred to our clinic for endoscopic therapy. Her past medical history was of an acute recurrent pancreatitis of a couple of years’ duration, and had been diagnosed with celiac disease. Endoscopic ultrasound revealed severe chronic pancreatitis, with total villous atrophy and flat-shaped duodenal mucosa. The patient was then treated with a combination of gluten-free diet and pancreatic enzymes, with this approach patient showed a dramatic improvement in her symptoms and soon started tolerating the GFD. The patient is free of abdominal pain and has had significant weight gain. In this brief review we reported this and present a literature review.